Name of the Post : Senior Research Fellow
No.of.Post : 01
Project Duration : The duration of the project is upto May 2021. Stipend shall be given
as per the CSIR rule.
Summary of the Proposal : Respiratory syncytial (RSV) is the major pathogen of acute
respiratory tract. The G protein of RSV is involved in attachment of virion with the host
cell. Glycosaminoglycans (GAGs) present on the surface of mammalian cells act as
receptors for RSV. The wild type protein has been cloned, expressed, purified and
characterized in a previous investigation. We propose to generate some mutants of the G
protein by site directed mutagenesis in the present proposal. The mutant proteins will be
characterized by using biophysical methods. The structures of wild type and mutant
proteins will be compared in terms of their conformational changes and stability.
Different ligands (GAGs, CX3CR1 and inhibitors) will be docked with the modeled
structures of wild type and mutant G proteins. High affinity ligands will be identified and
synthesized commercially. The protein-ligand interactions will be studied by fluorescence
and isothermal calorimeter. The interaction of the G protein with receptors is envisaged
to facilitate drug designing efforts.
(1) M.Sc. degree in Life Sciences or allied subjects.
(2) Minimum 2 years of research experience after post-graduation as evidenced from
published papers in standard refereed journals.
Desirable : Research experience in the field of cloning, expression and purification.
Expertise in characterization of proteins using biophysical methods like circular
dichorism, fluorescence and dynamic light scattering spectroscopy.
How to Apply:
Applications with updated hard copy of the CV should reach the “Office, Centre for
Interdisciplinary Research in Basic Sciences, S. Ramanujan Block, Jamia Millia
Islamia, New Delhi-110025” on or before 9th February 2018. Short listed candidates
shall be communicated by e-mail to appear in person with original certificates for the
interview. Kindly mention your mobile number and E-mail ID in the CV.
Dr. Shama Parveen
Centre for Interdisciplinary Research in Basic Sciences
Jamia Millia Islamia
Application Deadline – on or before 9th February 2018